Cat.No：GM-28954AB
Product：Anti-H_TNFRSF9(4-1BB) hIgG4 Antibody (Urelumab)
Cat.No：GM-28954AB
Product：Anti-H_TNFRSF9(4-1BB) hIgG4 Antibody (Urelumab)
GM-28954AB-10 10 μg
GM-28954AB-100 100 μg
GM-28954AB-1000 1mg
Species Reactivity Human; Cynomolgus
Clone Urelumab
Source/Isotype Monoclonal Human IgG4 /κ
Application Flow Cytometry; Activation assay
Specificity Detects 4-1BB
Gene TNFRSF9
Other Names CD137, CDw137, ILA, IMD109
Gene ID 3604
Background 4-1BB, as one representative TNF receptor family co-stimulatory receptor, is expressed on a wide variety of cell types, including activated T cells, NK cells, DCs, B cells,monocytes, and neutrophils. 4-1BBL–4-1BB interaction can trigger an activation signal in all these cell types. However, anti-4-1BB-induced CD8+ T responses were thought to play a dominant role in anti-tumor immunity. Anti-4-1BB agonistic Abs could induce more effector molecules released from CD8+ T cells, increase proliferation and decrease apoptosis of CD8+ T cells, which all count for the enhanced anti-tumor immunity.It specifically binds to and ctivates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-28954AB
Product：Anti-H_TNFRSF9(4-1BB) hIgG4 Antibody (Urelumab)
GM-28954AB-10 10 μg
GM-28954AB-100 100 μg
GM-28954AB-1000 1mg
Species Reactivity Human; Cynomolgus
Clone Urelumab
Source/Isotype Monoclonal Human IgG4 /κ
Application Flow Cytometry; Activation assay
Specificity Detects 4-1BB
Gene TNFRSF9
Other Names CD137, CDw137, ILA, IMD109
Gene ID 3604
Background 4-1BB, as one representative TNF receptor family co-stimulatory receptor, is expressed on a wide variety of cell types, including activated T cells, NK cells, DCs, B cells,monocytes, and neutrophils. 4-1BBL–4-1BB interaction can trigger an activation signal in all these cell types. However, anti-4-1BB-induced CD8+ T responses were thought to play a dominant role in anti-tumor immunity. Anti-4-1BB agonistic Abs could induce more effector molecules released from CD8+ T cells, increase proliferation and decrease apoptosis of CD8+ T cells, which all count for the enhanced anti-tumor immunity.It specifically binds to and ctivates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
