Cat. No：GM-88205AB
Product：Anti-ASGR1 hIgG1 Antibody(4A2.001)
Cat. No：GM-88205AB
Product：Anti-ASGR1 hIgG1 Antibody(4A2.001)
GM-88205AB-10 10 μg
GM-88205AB-100 100 μg
GM-88205AB-1000 1mg
Species Reactivity | Human; Cynomolgus |
Clone | 4A2.001 |
Source/Isotype | Human IgG1(SEFL2), kappa |
Application | Flow Cytometry; Bioactivity-ELISA |
Target | Detects ASGR1 |
Gene | ASGR1 |
Other Names | ASGPR, ASGPR1, CLEC4H1, HL-1 |
Gene ID | 432 (Human); 102139430 (Cynomolgus) |
Background | ASGR1 (Asialoglycoprotein Receptor 1) is a scavenger receptor expressed on the surface of hepatic sinusoidal endothelial cells, forming a trimeric receptor complex with ASGR2, and primarily clears desialylated glycoproteins while modulating the half-life of plasma glycoproteins to participate in metabolism and immune homeostasis. Its potential applications in antibody research include targeting ASGR1 to achieve liver-specific drug delivery and glycoengineering optimization of antibody–drug conjugates (ADCs) to enhance hepatic uptake, reduce non-hepatic distribution, and potentially modulate circulating half-life. Additionally, probes and imaging agents based on ASGR1 glycan selectivity hold promise for liver diagnostics, with in vivo and in vitro models used to assess how different glycan modifications influence binding affinity, pharmacokinetics, and safety profiles. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
Cat. No：GM-88205AB
Product：Anti-ASGR1 hIgG1 Antibody(4A2.001)
GM-88205AB-10 10 μg
GM-88205AB-100 100 μg
GM-88205AB-1000 1mg
Species Reactivity | Human; Cynomolgus |
Clone | 4A2.001 |
Source/Isotype | Human IgG1(SEFL2), kappa |
Application | Flow Cytometry; Bioactivity-ELISA |
Target | Detects ASGR1 |
Gene | ASGR1 |
Other Names | ASGPR, ASGPR1, CLEC4H1, HL-1 |
Gene ID | 432 (Human); 102139430 (Cynomolgus) |
Background | ASGR1 (Asialoglycoprotein Receptor 1) is a scavenger receptor expressed on the surface of hepatic sinusoidal endothelial cells, forming a trimeric receptor complex with ASGR2, and primarily clears desialylated glycoproteins while modulating the half-life of plasma glycoproteins to participate in metabolism and immune homeostasis. Its potential applications in antibody research include targeting ASGR1 to achieve liver-specific drug delivery and glycoengineering optimization of antibody–drug conjugates (ADCs) to enhance hepatic uptake, reduce non-hepatic distribution, and potentially modulate circulating half-life. Additionally, probes and imaging agents based on ASGR1 glycan selectivity hold promise for liver diagnostics, with in vivo and in vitro models used to assess how different glycan modifications influence binding affinity, pharmacokinetics, and safety profiles. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
