NECTIN4 (Nectin Cell Adhesion Molecule 4) is a transmembrane protein belonging to the Nectin protein family, also referred to as PVRL4 (Poliovirus Receptor-Related 4). NECTIN4 is a cell adhesion molecule closely associated with regulating cell-cell interactions, cell polarity, and tissue integrity. In normal tissues, it is primarily expressed in the placenta and embryonic development tissues. However, under pathological conditions, such as in various cancers, its expression is significantly upregulated.
Genomeditech provides resources related to NECTIN4, including expression cell lines, proteins, and antibodies, which can be used for in vitro evaluation of NECTIN4-related drug efficacy.