GPC3 (Glypican-3) is a gene encoding a cell surface heparan sulfate proteoglycan belonging to the glypican family, anchored to the cell membrane via glycosylphosphatidylinositol (GPI). GPC3 is abundantly expressed during embryonic development but limited in normal adult tissues. It is highly expressed on various tumor cells, especially hepatocellular carcinoma (HCC), making it an important diagnostic and therapeutic target. GPC3 regulates cell growth and signaling pathways such as Wnt and Hedgehog, promoting tumor cell proliferation and invasion.
Genomeditech provides GPC3-related expression cell lines, proteins, antibodies, and resources for in vitro drug assessment.