NKp30 (Natural Killer Cell Protein 30) is a receptor expressed on the surface of natural killer (NK) cells and belongs to the Natural Cytotoxicity Receptors (NCRs) family. It is primarily expressed in NK cells. NKp30 is an activating receptor that, upon binding to its ligands, triggers the cytotoxic functions of NK cells. By recognizing specific ligands on the surface of tumor cells or virus-infected cells, NKp30 mediates the killing of target cells by NK cells. Additionally, it plays a role in immune regulation, such as enhancing immune responses through the secretion of cytokines like IFN-γ. The primary ligand for NKp30 is NCR3LG1 (Natural Cytotoxicity Triggering Receptor Ligand 1), also known as B7-H6, a molecule expressed on the surface of tumor cells. The high expression of B7-H6 is associated with the occurrence and progression of various cancers, making it a potential target for tumor immunotherapy.
Genomeditech provides a range of research tools related to the NKp30 and B7-H6 targets, including overexpression cell lines, functional cell lines, and antibodies. These resources comprehensively support the in vitro activity validation of antibodies targeting NKp30 and B7-H6. They offer strong support for researchers in evaluating and optimizing drug development, facilitating their application and translation in tumor immunotherapy.
