CEACAM (Carcinoembryonic Antigen-Related Cell Adhesion Molecule) Family comprises genes encoding transmembrane cell adhesion molecules involved in cell-cell interactions and signaling. CEACAM members play critical roles in immune regulation, inflammation, and tumor development:
CEACAM5: Encodes carcinoembryonic antigen (CEA), highly expressed on many epithelial and tumor cells such as colon and lung cancer. CEACAM5 is involved in cell adhesion and signaling and serves as a tumor marker and immune therapy target.
CEACAM6: Mainly expressed in epithelial and some immune cells and overexpressed in cancers such as pancreatic and lung cancers. CEACAM6 promotes tumor invasion and drug resistance and is an important target for immunotherapy and ADC development.
CEACAM7: Highly expressed in normal colon tissue but significantly decreased in colon cancer, used as a biomarker for intestinal diseases. CEACAM7 regulates cell differentiation and adhesion and functions as a tumor suppressor.
CEACAM8: Primarily found on neutrophils and other leukocytes, regulating immune cell adhesion and migration and playing important roles in immune surveillance and inflammation.
Genomeditech offers CEACAM family-related expression cell lines, proteins, antibodies, and other resources for drug evaluation.
