CALCR (Calcitonin Receptor) is a transmembrane G protein-coupled receptor (GPCR) belonging to the Class B GPCR family. CALCR primarily binds to its ligand, calcitonin, to regulate calcium and phosphate metabolism, playing a role in bone metabolism, calcium homeostasis, and other physiological processes. CALCR is widely expressed in the skeletal system, kidneys, and central nervous system, and its dysfunction is associated with osteoporosis, metabolic bone diseases, and certain cancers. AMY1, AMY2, and AMY3 are subtypes of Amylin Receptors, which are heteromeric complexes formed by CALCR (Calcitonin Receptor) and RAMPs (Receptor Activity-Modifying Proteins). RAMPs are small transmembrane proteins that interact with CALCR to alter their ligand specificity and function. Depending on the type of RAMP that binds to CALCR, different AMY receptor subtypes are formed. AMY1: Composed of CALCR + RAMP1; AMY2: Composed of CALCR + RAMP2; AMY3: Composed of CALCR + RAMP3
Genomeditech provides a variety of research tools related to the CALCR target, including overexpression cell lines, functional cell lines, proteins, and antibodies. These resources comprehensively support the in vitro activity validation of related drugs, providing strong support for researchers in evaluating and optimizing drug development, and facilitating their application and translation in disease prevention and treatment.
