NRAS (Neuroblastoma RAS Viral Oncogene Homolog) is a proto-oncogene and a member of the RAS gene family, which includes KRAS, HRAS, and NRAS. The NRAS gene encodes the NRAS protein, a small GTPase that acts as a molecular switch in cells, regulating critical biological processes such as cell proliferation, differentiation, and survival. NRAS mutations are closely associated with the development of various tumors. These mutations show a high incidence in cancers such as melanoma, colorectal cancer, and acute myeloid leukemia.
Ba/F3 cells are a cell line derived from mouse IL-3-dependent pro-B cells, which require interleukin-3 (IL-3) for survival and proliferation. When a mutant NRAS gene is introduced, these cells become independent of IL-3 and start proliferating through NRAS-mediated signaling pathways. Therefore, NRAS Ba/F3 cells are a classic tool for validating the oncogenic activity of NRAS mutations and are also widely used for screening NRAS inhibitors.
Genomeditech provides Ba/F3 cell lines with targets such as NRAS, supporting the screening, activity validation, and in vitro efficacy studies of KRAS inhibitors.
