CGRP (Calcitonin Gene-Related Peptide) is a peptide molecule encoded by the CALCA gene (Calcitonin-related polypeptide alpha gene). It exists in two isoforms, α-CGRP and β-CGRP, which are mainly produced through alternative splicing. CGRP is widely distributed in the central and peripheral nervous systems and acts as an important neurotransmitter and neuromodulator, participating in various physiological and pathological processes.
CALCRL (Calcitonin Receptor-Like Receptor) is a G protein-coupled receptor (GPCR) that plays a vital role in multiple endocrine and nervous system functions. CALCRL itself does not have ligand specificity; its function depends on its interaction with Receptor Activity-Modifying Proteins (RAMPs). Different RAMP protein isoforms can combine with CALCRL to form different receptor complexes, conferring distinct ligand specificities and functions.
Genomeditech provides resources related to CGRP targets, including functional cell lines, expression cell lines, proteins, and antibodies, to support the activity validation and in vitro efficacy evaluation of CGRP-related drugs.
