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Pseudovirus control material
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Cytokine Immune checkpoint TAA Kinase NK Antibody function Immunotherapy target LILR TNF WNT GPCR CLDN Others
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Current position：Product Center > Antibodies > Biosimilar Antibodies
Immune checkpoint
Background

Immune checkpoints are a series of molecules expressed on immune cells that regulate the degree of immune activation. They play a crucial role in preventing autoimmune reactions where the immune system attacks normal cells. When the body's immune function is stimulated, it becomes activated but not excessively so, thanks to the "immune checkpoint molecules" acting like a brake system in a car. This timely braking helps maintain the immune system's activation within normal limits, preventing overactivation. Abnormal expression and function of immune checkpoint molecules are significant factors in the development of many diseases. If these molecules are overexpressed or too strong, immune function is suppressed, leading to reduced immunity. Conversely, if the immune inhibitory function of these molecules is poor, immune function becomes abnormal. Tumor cells express substances that activate immune checkpoints, which act as a brake to prevent antigen presentation to T cells. This hinders the antigen presentation process in the tumor immune microenvironment, inhibiting the immune function of T cells and allowing the tumor to evade surveillance and survive.


Products
Target Cat. No. Product
PD1-PDL1
GM-81957AB
Anti-Canine_PD1 mIgG2a Antibody(4F12-E6)
PD1-PDL1
GM-79817AB
Anti-PD-L2 hIgG1 Antibody(Hz25G4-1.1)
PD1-PDL1
GM-32251AB
Anti-H_PDCD1LG2 mIgG1 Antibody(3G2)
PD1-PDL1
GM-60293AB
Anti-CTLA-4/PD-1 hIgG1 Bispecific Antibody(Cadonilimab)
PD1-PDL1
GM-52674AB
Anti-PD1 hIgG4 Antibody(Pembrolizumab)
PD1-PDL1
GM-28957AB
Anti-H_PDCD1(PD1) hIgG1 Antibody(Budigalimab)
PD1
GM-87755MAB
Anti-PD1 hIgG4 Reference Antibody (Sintbio)
PD1
GM-87759MAB
Anti-PD1 hIgG4 Reference Antibody (Nivbio)
PD1
GM-87802MAB
Anti-PD1 hIgG4 Reference Antibody (Pembio)
PD1
GM-87803MAB
Anti-PD1 hIgG4 Reference Antibody(Cambio)
PD-L1
GM-86950AB
Anti-Mouse PD-L1 mIgG1 Antibody(10F.9G2)
PD-L1
GM-86859MAB
Anti-PD-1 hIgG4 Reference Antibody (Torbio)
PD-L1
GM-86861MAB
Anti-PD-1 hIgG4 Reference Antibody(Tislbio)
PD-L1
GM-86853MAB
Anti-PDL1 hIgG4 Reference Antibody(Adebio)
CD40
GM-86199AB
Anti-H_CD40 hIgG1 Antibody(ravagalimab)
CD40
GM-83977AB
Anti-H_CD40L hIgG1 Antibody(dapirolizumab)
CD40
GM-83978AB
Anti-H_CD40L hIgG1 Antibody(frexalimab)
CD40
GM-24025AB
Anti-H_CD40 hIgG1 Antibody(APX005M)
OX40
GM-82533AB
Anti-OX40L hIgG4 Antibody(Amlitelimab)
OX40
GM-23373AB
Anti-H_OX40 hIgG2 Antibody(Ivuxolimab)
OX40
GM-87799MAB
Anti-OX40L hIgG4 Reference Antibody (Amlbio)
OX40
GM-87694MAB
Anti-OX40L hIgG1 Reference Antibody (Oxebio)
Lag3
GM-51650AB
Anti-Lag3 hIgG4 Antibody(Relatlimab)
Lag3
GM-51647AB
Anti-Lag3 hIgG4 Antibody(IMP-7)
Lag3
GM-28753AB
Anti-H_LAG3 hIgG4 Antibody(Mavezelimab)
CD27-CD70
GM-24024AB
Anti-H_CD70 hIgG1 Antibody(Cusatuzumab)
CD27-CD70
GM-31740AB
Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)
CD47-SIRPα
GM-27657AB
Anti-CD47 hIgG4 Antibody(5F9)
CD28
GM-52277AB
Anti-CD28 hIgG4 Antibody(FR104)
CD28
GM-27197AB
Anti-H_CD28 hIgG4 Antibody(Theralizumab)
CD112-CD112R
GM-30125AB
Anti-H_NECTIN2(CD112) hIgG1 Antibody
CD112-CD112R
GM-48167AB
Anti-CD112R hIgG1 Antibody(SRF813)
HVEM
GM-49928AB
Anti-TNFRSF14(HVEM) hIgG4 Antibody
TREM
GM-30244AB
Anti-TREM2 hIgG1 Antibody
TREM
GM-22998AB
Anti-H_TREM2 Rat_IgG2b Antibody
TREM
GM-48593AB
Anti-H_TREM2 hIgG4 Antibody
HAVCR2(TIM3)
GM-50627AB
Anti-TIM3 hIgG2 Antibody(M6903)
HAVCR2(TIM3)
GM-27128AB
Anti-H_HAVCR2(TIM3) hIgG4 Antibody(Sabatolimab)
BTLA-HVEM
GM-50103AB
Anti-BTLA hIgG4 Antibody(22B3)
BTLA-HVEM
GM-28675AB
Anti-BTLA hIgG4 Antibody(Icatolimab)
CD200-CD200R
GM-48495AB
Anti-H_CD200 hIgG Antibody(Samalizumab)
CD200-CD200R
GM-48346AB
Anti-H_CD200R hIgG1 Antibody(huDX182)
CD200-CD200R
GM-48237AB
Anti-CD200R hIgG4 Antibody(I-4P)
CD200-CD200R
GM-48240AB
Anti-CD200R hIgG4 Antibody
CTLA4:CD80:CD86
GM-46075AB
Anti-H_CD80 hIgG1 Antibody(Galiximab)
CTLA4:CD80:CD86
GM-27203AB
Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab)
CTLA4
GM-87752AB
Anti-mouse CTLA4 mIgG2a Antibody(9D9)
CTLA4
GM-87801MAB
Anti-CTLA4 hIgG1 Reference Antibody (Ipibio)
SIGLEC8
GM-28730AB
Anti-H_SIGLEC8 hIgG1 Antibody(1H10)
4-1BB
GM-26840AB
Anti-H_4-1BB hIgG2 Antibody(Utomilumab)
4-1BB
GM-28954AB
Anti-H_TNFRSF9(4-1BB) hIgG4 Antibody (Urelumab)
SIGLEC15
GM-24717AB
Anti-Siglec15 mIgG2a Antibody(5G12)
TIGIT-PVR-CD155
GM-24029AB
Anti-H_Tigit hIgG1 Antibody(Vibostolimab)
TIGIT-PVR-CD155
GM-27659AB
Anti-H_PVRIG hIgG1 Antibody
SLC39A6
GM-26839AB
Anti-H_SLC39A6 hIgG1 Antibody(Ladiratuzumab)
SIGLEC9
GM-31414AB
Anti-siglec9 mIgG1 Antibody(2D4)
VTCN1(B7H4)
GM-24028AB
Anti-H_B7H4(VTCN1) hIgG1 Antibody(FPA150)
VTCN1(B7H4)
GM-86662MAB
Anti-H_B7H4 hIgG1 Reference Antibody(FPA150)
CD276(B7H3)
GM-24026AB
Anti-H_CD276(B7H3) hIgG1 Antibody（enoblituzumab）
SIRPA
GM-87750AB
Anti-mouse SIRPA Monoclonal Antibody(p84)
ITPRIPL1
GM-87827AB
Anti-H_ITPRIPL1 mIgG1 Antibody(13B7A6H3)
TREM
GM-26835AB
Anti-TREM1 hIgG1 Antibody
B7H3
GM-87345MAB
Anti-CD276(B7H3) hIgG1 Reference Antibody(Ifibio)
Product Center > Antibodies > Biosimilar Antibodies
classify
Immune checkpoint
Products
Target Cat. No. Product
PD1-PDL1
GM-81957AB
Anti-Canine_PD1 mIgG2a Antibody(4F12-E6)
PD1-PDL1
GM-79817AB
Anti-PD-L2 hIgG1 Antibody(Hz25G4-1.1)
PD1-PDL1
GM-32251AB
Anti-H_PDCD1LG2 mIgG1 Antibody(3G2)
PD1-PDL1
GM-60293AB
Anti-CTLA-4/PD-1 hIgG1 Bispecific Antibody(Cadonilimab)
PD1-PDL1
GM-52674AB
Anti-PD1 hIgG4 Antibody(Pembrolizumab)
PD1-PDL1
GM-28957AB
Anti-H_PDCD1(PD1) hIgG1 Antibody(Budigalimab)
PD1
GM-87755MAB
Anti-PD1 hIgG4 Reference Antibody (Sintbio)
PD1
GM-87759MAB
Anti-PD1 hIgG4 Reference Antibody (Nivbio)
PD1
GM-87802MAB
Anti-PD1 hIgG4 Reference Antibody (Pembio)
PD1
GM-87803MAB
Anti-PD1 hIgG4 Reference Antibody(Cambio)
PD-L1
GM-86950AB
Anti-Mouse PD-L1 mIgG1 Antibody(10F.9G2)
PD-L1
GM-86859MAB
Anti-PD-1 hIgG4 Reference Antibody (Torbio)
PD-L1
GM-86861MAB
Anti-PD-1 hIgG4 Reference Antibody(Tislbio)
PD-L1
GM-86853MAB
Anti-PDL1 hIgG4 Reference Antibody(Adebio)
CD40
GM-86199AB
Anti-H_CD40 hIgG1 Antibody(ravagalimab)
CD40
GM-83977AB
Anti-H_CD40L hIgG1 Antibody(dapirolizumab)
CD40
GM-83978AB
Anti-H_CD40L hIgG1 Antibody(frexalimab)
CD40
GM-24025AB
Anti-H_CD40 hIgG1 Antibody(APX005M)
OX40
GM-82533AB
Anti-OX40L hIgG4 Antibody(Amlitelimab)
OX40
GM-23373AB
Anti-H_OX40 hIgG2 Antibody(Ivuxolimab)
OX40
GM-87799MAB
Anti-OX40L hIgG4 Reference Antibody (Amlbio)
OX40
GM-87694MAB
Anti-OX40L hIgG1 Reference Antibody (Oxebio)
Lag3
GM-51650AB
Anti-Lag3 hIgG4 Antibody(Relatlimab)
Lag3
GM-51647AB
Anti-Lag3 hIgG4 Antibody(IMP-7)
Lag3
GM-28753AB
Anti-H_LAG3 hIgG4 Antibody(Mavezelimab)
CD27-CD70
GM-24024AB
Anti-H_CD70 hIgG1 Antibody(Cusatuzumab)
CD27-CD70
GM-31740AB
Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab)
CD47-SIRPα
GM-27657AB
Anti-CD47 hIgG4 Antibody(5F9)
CD28
GM-52277AB
Anti-CD28 hIgG4 Antibody(FR104)
CD28
GM-27197AB
Anti-H_CD28 hIgG4 Antibody(Theralizumab)
CD112-CD112R
GM-30125AB
Anti-H_NECTIN2(CD112) hIgG1 Antibody
CD112-CD112R
GM-48167AB
Anti-CD112R hIgG1 Antibody(SRF813)
HVEM
GM-49928AB
Anti-TNFRSF14(HVEM) hIgG4 Antibody
TREM
GM-30244AB
Anti-TREM2 hIgG1 Antibody
TREM
GM-22998AB
Anti-H_TREM2 Rat_IgG2b Antibody
TREM
GM-48593AB
Anti-H_TREM2 hIgG4 Antibody
HAVCR2(TIM3)
GM-50627AB
Anti-TIM3 hIgG2 Antibody(M6903)
HAVCR2(TIM3)
GM-27128AB
Anti-H_HAVCR2(TIM3) hIgG4 Antibody(Sabatolimab)
BTLA-HVEM
GM-50103AB
Anti-BTLA hIgG4 Antibody(22B3)
BTLA-HVEM
GM-28675AB
Anti-BTLA hIgG4 Antibody(Icatolimab)
CD200-CD200R
GM-48495AB
Anti-H_CD200 hIgG Antibody(Samalizumab)
CD200-CD200R
GM-48346AB
Anti-H_CD200R hIgG1 Antibody(huDX182)
CD200-CD200R
GM-48237AB
Anti-CD200R hIgG4 Antibody(I-4P)
CD200-CD200R
GM-48240AB
Anti-CD200R hIgG4 Antibody
CTLA4:CD80:CD86
GM-46075AB
Anti-H_CD80 hIgG1 Antibody(Galiximab)
CTLA4:CD80:CD86
GM-27203AB
Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab)
CTLA4
GM-87752AB
Anti-mouse CTLA4 mIgG2a Antibody(9D9)
CTLA4
GM-87801MAB
Anti-CTLA4 hIgG1 Reference Antibody (Ipibio)
SIGLEC8
GM-28730AB
Anti-H_SIGLEC8 hIgG1 Antibody(1H10)
4-1BB
GM-26840AB
Anti-H_4-1BB hIgG2 Antibody(Utomilumab)
4-1BB
GM-28954AB
Anti-H_TNFRSF9(4-1BB) hIgG4 Antibody (Urelumab)
SIGLEC15
GM-24717AB
Anti-Siglec15 mIgG2a Antibody(5G12)
TIGIT-PVR-CD155
GM-24029AB
Anti-H_Tigit hIgG1 Antibody(Vibostolimab)
TIGIT-PVR-CD155
GM-27659AB
Anti-H_PVRIG hIgG1 Antibody
SLC39A6
GM-26839AB
Anti-H_SLC39A6 hIgG1 Antibody(Ladiratuzumab)
SIGLEC9
GM-31414AB
Anti-siglec9 mIgG1 Antibody(2D4)
VTCN1(B7H4)
GM-24028AB
Anti-H_B7H4(VTCN1) hIgG1 Antibody(FPA150)
VTCN1(B7H4)
GM-86662MAB
Anti-H_B7H4 hIgG1 Reference Antibody(FPA150)
CD276(B7H3)
GM-24026AB
Anti-H_CD276(B7H3) hIgG1 Antibody（enoblituzumab）
SIRPA
GM-87750AB
Anti-mouse SIRPA Monoclonal Antibody(p84)
ITPRIPL1
GM-87827AB
Anti-H_ITPRIPL1 mIgG1 Antibody(13B7A6H3)
TREM
GM-26835AB
Anti-TREM1 hIgG1 Antibody
B7H3
GM-87345MAB
Anti-CD276(B7H3) hIgG1 Reference Antibody(Ifibio)
Background

Immune checkpoints are a series of molecules expressed on immune cells that regulate the degree of immune activation. They play a crucial role in preventing autoimmune reactions where the immune system attacks normal cells. When the body's immune function is stimulated, it becomes activated but not excessively so, thanks to the "immune checkpoint molecules" acting like a brake system in a car. This timely braking helps maintain the immune system's activation within normal limits, preventing overactivation. Abnormal expression and function of immune checkpoint molecules are significant factors in the development of many diseases. If these molecules are overexpressed or too strong, immune function is suppressed, leading to reduced immunity. Conversely, if the immune inhibitory function of these molecules is poor, immune function becomes abnormal. Tumor cells express substances that activate immune checkpoints, which act as a brake to prevent antigen presentation to T cells. This hinders the antigen presentation process in the tumor immune microenvironment, inhibiting the immune function of T cells and allowing the tumor to evade surveillance and survive.


Catologe
Anti-H_CD40 hIgG1 Antibody(ravagalimab) Anti-H_CD40L hIgG1 Antibody(dapirolizumab) Anti-OX40L hIgG4 Antibody(Amlitelimab) Anti-Lag3 hIgG4 Antibody(Relatlimab) Anti-H_LAG3 hIgG4 Antibody(Mavezelimab) Anti-H_CD70 hIgG1 Antibody(Cusatuzumab) Anti-H_TREM2 hIgG4 Antibody Anti-BTLA hIgG4 Antibody(22B3) Anti-CD200R hIgG4 Antibody(I-4P) Anti-H_SLC39A6 hIgG1 Antibody(Ladiratuzumab) Anti-H_B7H4(VTCN1) hIgG1 Antibody(FPA150) Anti-H_B7H4 hIgG1 Reference Antibody(FPA150) Anti-CTLA-4/PD-1 hIgG1 Bispecific Antibody(Cadonilimab) Anti-PD1 hIgG4 Antibody(Pembrolizumab) Anti-H_CD276(B7H3) hIgG1 Antibody（enoblituzumab） Anti-H_PDCD1(PD1) hIgG1 Antibody(Budigalimab) Anti-H_CD40 hIgG1 Antibody(APX005M) Anti-H_OX40 hIgG2 Antibody(Ivuxolimab) Anti-Lag3 hIgG4 Antibody(IMP-7) Anti-CD47 hIgG4 Antibody(5F9) Anti-CD28 hIgG4 Antibody(FR104) Anti-H_NECTIN2(CD112) hIgG1 Antibody Anti-CD112R hIgG1 Antibody(SRF813) Anti-H_HAVCR2(TIM3) hIgG4 Antibody(Sabatolimab) Anti-H_CD200 hIgG Antibody(Samalizumab) Anti-CD200R hIgG4 Antibody Anti-H_CD80 hIgG1 Antibody(Galiximab) Anti-H_SIGLEC8 hIgG1 Antibody(1H10) Anti-H_4-1BB hIgG2 Antibody(Utomilumab) Anti-H_Tigit hIgG1 Antibody(Vibostolimab) Anti-H_PVRIG hIgG1 Antibody Anti-siglec9 mIgG1 Antibody(2D4) Anti-Siglec15 mIgG2a Antibody(5G12) Anti-TIM3 hIgG2 Antibody(M6903) Anti-PD-L2 hIgG1 Antibody(Hz25G4-1.1) Anti-TNFRSF14(HVEM) hIgG4 Antibody Anti-H_TREM2 Rat_IgG2b Antibody Anti-BTLA hIgG4 Antibody(Icatolimab) Anti-TREM2 hIgG1 Antibody Anti-H_CD274(PDL1) hIgG1 Antibody(Atezolizumab) Anti-H_CD28 hIgG4 Antibody(Theralizumab) Anti-Canine_PD1 mIgG2a Antibody(4F12-E6) Anti-H_PDCD1LG2 mIgG1 Antibody(3G2) Anti-H_TNFRSF9(4-1BB) hIgG4 Antibody (Urelumab) Anti-H_CD40L hIgG1 Antibody(frexalimab) Anti-H_CD200R hIgG1 Antibody(huDX182) Anti-H_CTLA-4 hIgG1 Antibody(Ipilimumab) Anti-mouse CTLA4 mIgG2a Antibody(9D9) Anti-TREM1 hIgG1 Antibody Anti-CTLA4 hIgG1 Reference Antibody (Ipibio) Anti-CD276(B7H3) hIgG1 Reference Antibody(Ifibio) Anti-OX40L hIgG4 Reference Antibody (Amlbio) Anti-OX40L hIgG1 Reference Antibody (Oxebio) Anti-mouse SIRPA RIgG1 Antibody(p84) Anti-PD1 hIgG4 Reference Antibody (Sintbio) Anti-PD1 hIgG4 Reference Antibody (Nivbio) Anti-PD1 hIgG4 Reference Antibody (Pembio) Anti-PD1 hIgG4 Reference Antibody(Cambio) Anti-Mouse PD-L1 mIgG1 Antibody(10F.9G2) Anti-PD-1 hIgG4 Reference Antibody (Torbio) Anti-PD-1 hIgG4 Reference Antibody (Tislbio) Anti-PDL1 hIgG4 Reference Antibody (Adebio) Anti-H_ITPRIPL1 mIgG1 Antibody(13B7A6H3)
Plasmid
Stock Plasmid
过表达现货 干扰现货
Reporter Plasmid
报告基因质粒-Luc 报告基因质粒-GFP
IPS相关质粒 自噬荧光单标质粒 空载体 细胞示踪质粒
Cell lines
Cytokines
Immune checkpoints
GPCR
CLDN
TAA
Kinase
TLR
NK
Antibody function
Immunotherapy target
In vivo imaging
TNF
LILR
WNT
Others
Reference cells
Molecular Reference Standards
gDNA ctDNA
Reporter gene detection-related reagents
GMOne-Step GMOne-Step 2.0 GMBright One-Step GMSteady One-Step 双荧光素酶报告基因检测试剂盒 D-Luciferin
Lentivirus
过表达慢病毒 报告基因慢病毒 活体成像慢病毒 IPS相关慢病毒 永生化慢病毒 自噬慢病毒 CRE慢病毒 荧光对照慢病毒
Proteins
Cytokines
TAA
Immune checkpoints
Immunotherapy target
GPCR
TNF
Kinase
Others
Pseudovirus control material
Coronavirus-Like Pseudovirus 流感病毒类 副流感病毒类 呼吸道合胞病毒类 鼻病毒类 人偏肺病毒类 猴痘类
Reagents related to cell function detection and analysis
GMTiter TM Luminescent Cell Viability Assay CCK8检测试剂盒
Adeno-Associated Virus (AAV)
光遗传 化学遗传 钙成像 Cre重组酶 常用对照
Antibodies
In Vivo MAb Antibodies
Isotype Control Antibody Anti-Mouse Antibody
Anti-payload antibodies
Anti-payload antibodies Positive control Negative Control
Loading Controls Antibodies & Tag Antibodies
Loading Controls Anitibodies Tag Antibodies
Biosimilar Antibodies
Cytokine Immune checkpoint TAA Kinase NK Antibody function Immunotherapy target LILR TNF WNT GPCR CLDN Others
Pseudovirus
SARS-CoV-2 pseudovirus 狂犬假病毒 非典假病毒 VSV假病毒
Genoagent (Brand name of reagents)
lentiviral-packaging-tool
慢病毒包装试剂盒 慢病毒浓缩试剂盒
Transfection Reagent
GMTrans Liposomal Transfection Reagent HG-TransGene transfection reagent HG-Trans293 Transfection Reagent
支原体清除试剂 抗生素 基因敲除试剂盒 Polybrene（聚凝胺） Switch-On Reagent 金黄色葡萄球菌肠毒素 E
Products
Plasmid Lentivirus Adeno-associated virus Cell lines Proteins Antibodies Molecular Reference Standards Pseudovirus control material pseudovirus Reporter gene detection-related reagents Reagents related to cell function detection and analysis Genoagent (Brand name of reagents)
Services
Lentivirus Cell line Development Protein Expression Plasmid DNA Preparation Services Adeno-associated Virus Cell-based Assay Antibody Services Reporter Gene Detection Services
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Email address：mkt.genomeditech@gmail.com
Company address：5th Floor, Building 1, Lane 299, Kangwei Road, Pudong New District, Shanghai
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