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PD-1/VEGF:GlycoMimetics enters into acquisition agreement with Crescent biopharma
吉满生物
2024-11-01

October 29, 2024, GlycoMimetics enters into acquisition agreement with Crescent biopharma.Crescent’s lead program CR-001, a tetravalent PD-1 x VEGF bispecific antibody incorporating the cooperative binding mechanism underpinning recent immuno-oncology breakthrough, expected to have preliminary proof of concept data in 2H26.

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Indeed, treatment regimens including combinations of anti-PD-1/PD-L1 antibodies and VEGF antibodies have been approved for use in clinical settings for non-squamous non-small cell lung cancer (NSCLC) and hepatocellular carcinoma. Moreover, many clinical trials are currently underway, making it one of the most promising combinations in cancer immunotherapy.

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IL-5: a key regulator of eosinophilic inflammation
Interleukin-5 (IL-5) is a key driver of eosinophilic inflammation, underlying conditions such as severe asthma, chronic rhinosinusitis with nasal polyps, and other allergic or inflammatory diseases. Recent advances in IL-5–targeted therapies, including GSK’s next-generation ultra-long-acting antibody Depemokimab (Exdensur), are transforming the treatment landscape. With extended dosing intervals and proven efficacy, these therapies offer new hope for improved patient outcomes and quality of life.
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2025-12-24
IL-5: a key regulator of eosinophilic inflammation
Interleukin-5 (IL-5) is a key driver of eosinophilic inflammation, underlying conditions such as severe asthma, chronic rhinosinusitis with nasal polyps, and other allergic or inflammatory diseases. Recent advances in IL-5–targeted therapies, including GSK’s next-generation ultra-long-acting antibody Depemokimab (Exdensur), are transforming the treatment landscape. With extended dosing intervals and proven efficacy, these therapies offer new hope for improved patient outcomes and quality of life.
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A recent Nature Aging study reveals that senescent tumor-adjacent epithelial cells secrete GDF15, driving colorectal cancer progression via a metabolic–epigenetic feedback loop. This expands GDF15’s role beyond tumor cells to its influence on the surrounding microenvironment.

Emerging as a hub connecting tumor growth, immune evasion, and systemic metabolism, GDF15 is a promising target across oncology, cancer cachexia, obesity, and metabolic diseases. Monoclonal antibodies like Ponsegromab and Visugromab are showing encouraging results in early clinical trials.
Current position:News > News > Insights
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PD-1/VEGF:GlycoMimetics enters into acquisition agreement with Crescent biopharma
吉满生物
2024-11-01

October 29, 2024, GlycoMimetics enters into acquisition agreement with Crescent biopharma.Crescent’s lead program CR-001, a tetravalent PD-1 x VEGF bispecific antibody incorporating the cooperative binding mechanism underpinning recent immuno-oncology breakthrough, expected to have preliminary proof of concept data in 2H26.

图片

图片

Indeed, treatment regimens including combinations of anti-PD-1/PD-L1 antibodies and VEGF antibodies have been approved for use in clinical settings for non-squamous non-small cell lung cancer (NSCLC) and hepatocellular carcinoma. Moreover, many clinical trials are currently underway, making it one of the most promising combinations in cancer immunotherapy.

learn more about our catalog


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