Cat. No：GM-C12968
Product：H_ACE2 HEK-293T Cell Line
Cat. No：GM-C12968
Product：H_ACE2 HEK-293T Cell Line
Cell Growth Medium：DMEM+10% FBS+1% P.S+0.75 μg/mL Puromycin
Cell Freezing Medium： 90% FBS+10% DMSO
Angiotensin-converting enzyme (ACE) 2 is a homolog of carboxypeptidase ACE, which generates angiotensin II, the main active peptide of the renin-angiotensin system (RAS). ACE2 is a powerful negative regulator of RAS, balancing the various functions of ACE. By targeting angiotensin II, ACE2 demonstrates protective effects in the cardiovascular system and many other organs. The S protein is a key protein that allows coronaviruses to bind to the ACE2 receptor on the surface of host cells, thereby mediating viral entry into host cells.
The S protein is the most important surface membrane protein of coronaviruses, consisting of two subunits, S1 and S2. The S1 subunit contains the receptor-binding domain (RBD), which is responsible for recognizing the receptors on cells. The S2 subunit contains essential components required for membrane fusion. Studies have shown that the S protein mediates receptor binding and membrane fusion, playing a crucial role in the viral infection of host cells. Additionally, the S protein contains major antigens that stimulate neutralizing antibodies and important targets for cytotoxic lymphocytes, making it a key target for vaccine design, therapeutic antibodies, and diagnostic methods.
Wang J, Zhang Y, Hu S, Bai H, Xue Z, Liu Y, Ma W. Antiviral drugs suppress infection of 2019-nCoV spike pseudotyped virus by interacting with ACE2 protein. J Biochem Mol Toxicol. 2022 Feb;36(2):e22948. Epub 2021 Nov 10. PMID: 34755435; PMCID: PMC8646714.
Li X, Zhu W, Fan M, Zhang J, Peng Y, Huang F, Wang N, He L, Zhang L, Holmdahl R, Meng L, Lu S. Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification. Comput Struct Biotechnol J. 2021;19:1933-1943. Epub 2021 Apr 8. PMID: 33850607; PMCID: PMC8028701.
Zhang Y, Hu S, Wang J, Xue Z, Wang C, Wang N. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2. Virology. 2021 Feb;554:83-88. Epub 2020 Dec 16. PMID: 33387788; PMCID: PMC7744032.
Cat. No：GM-C12968
Product：H_ACE2 HEK-293T Cell Line
Cell Growth Medium：DMEM+10% FBS+1% P.S+0.75 μg/mL Puromycin
Cell Freezing Medium： 90% FBS+10% DMSO
Angiotensin-converting enzyme (ACE) 2 is a homolog of carboxypeptidase ACE, which generates angiotensin II, the main active peptide of the renin-angiotensin system (RAS). ACE2 is a powerful negative regulator of RAS, balancing the various functions of ACE. By targeting angiotensin II, ACE2 demonstrates protective effects in the cardiovascular system and many other organs. The S protein is a key protein that allows coronaviruses to bind to the ACE2 receptor on the surface of host cells, thereby mediating viral entry into host cells.
The S protein is the most important surface membrane protein of coronaviruses, consisting of two subunits, S1 and S2. The S1 subunit contains the receptor-binding domain (RBD), which is responsible for recognizing the receptors on cells. The S2 subunit contains essential components required for membrane fusion. Studies have shown that the S protein mediates receptor binding and membrane fusion, playing a crucial role in the viral infection of host cells. Additionally, the S protein contains major antigens that stimulate neutralizing antibodies and important targets for cytotoxic lymphocytes, making it a key target for vaccine design, therapeutic antibodies, and diagnostic methods.
Wang J, Zhang Y, Hu S, Bai H, Xue Z, Liu Y, Ma W. Antiviral drugs suppress infection of 2019-nCoV spike pseudotyped virus by interacting with ACE2 protein. J Biochem Mol Toxicol. 2022 Feb;36(2):e22948. Epub 2021 Nov 10. PMID: 34755435; PMCID: PMC8646714.
Li X, Zhu W, Fan M, Zhang J, Peng Y, Huang F, Wang N, He L, Zhang L, Holmdahl R, Meng L, Lu S. Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification. Comput Struct Biotechnol J. 2021;19:1933-1943. Epub 2021 Apr 8. PMID: 33850607; PMCID: PMC8028701.
Zhang Y, Hu S, Wang J, Xue Z, Wang C, Wang N. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2. Virology. 2021 Feb;554:83-88. Epub 2020 Dec 16. PMID: 33387788; PMCID: PMC7744032.
