Cat.No：GM-24027AB
Product：Anti-H_MSLN hIgG1 Antibody(Amatuximab)
Cat.No：GM-24027AB
Product：Anti-H_MSLN hIgG1 Antibody(Amatuximab)
GM-24027AB-10 10 μg
GM-24027AB-100 100 μg
GM-24027AB-1000 1mg
Species Reactivity Human
Clone Amatuximab
Source/Isotype Monoclonal Human IgG1, κ
Application Flow Cytometry
Specificity Detects MSLN
Gene MSLN
Other Names MPF, SMRP
Gene ID 10232(human)
Background MSLN is over expressed in several human tumors, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, lung adenocarcinoma, and cholangiocarcinoma. MSLN binds MUC16 (also known as CA125), indicating that the interaction of mesothelin and MUC16 may contribute to the implantation and peritoneal spread of tumors by cell adhesion. The region (residues 296-359) consisting of 64 amino acids at the N-terminus of cell surface mesothelin has been identified as the functional binding domain (named IAB) for MUC16/CA125, suggesting the mechanism of mesothelin acting as a MUC16/CA125 functional partner in cancer development. MSLN is a tumor differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Since mesothelin is overexpressed in several cancers and is immunogenic, the protein could be exploited as tumor marker or as the antigenic target of a therapeutic cancer vaccine.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-24027AB
Product：Anti-H_MSLN hIgG1 Antibody(Amatuximab)
GM-24027AB-10 10 μg
GM-24027AB-100 100 μg
GM-24027AB-1000 1mg
Species Reactivity Human
Clone Amatuximab
Source/Isotype Monoclonal Human IgG1, κ
Application Flow Cytometry
Specificity Detects MSLN
Gene MSLN
Other Names MPF, SMRP
Gene ID 10232(human)
Background MSLN is over expressed in several human tumors, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma, lung adenocarcinoma, and cholangiocarcinoma. MSLN binds MUC16 (also known as CA125), indicating that the interaction of mesothelin and MUC16 may contribute to the implantation and peritoneal spread of tumors by cell adhesion. The region (residues 296-359) consisting of 64 amino acids at the N-terminus of cell surface mesothelin has been identified as the functional binding domain (named IAB) for MUC16/CA125, suggesting the mechanism of mesothelin acting as a MUC16/CA125 functional partner in cancer development. MSLN is a tumor differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Since mesothelin is overexpressed in several cancers and is immunogenic, the protein could be exploited as tumor marker or as the antigenic target of a therapeutic cancer vaccine.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
