Cat. No：GM-58915AB
Product：Anti-H_TNFSF15(TL1A) hIgG1 Antibody(Tulisokibart、PRA-023)
Cat. No：GM-58915AB
Product：Anti-H_TNFSF15(TL1A) hIgG1 Antibody(Tulisokibart、PRA-023)
GM-58915AB-10 10 μg
GM-58915AB-100 100 μg
GM-58915AB-1000 1 mg
Species Reactivity Human
Clone Tulisokibart/PRA-023
Source/Isotype Monoclonal Human IgG1 /κ
Application Flow Cytometry; Block assay
Specificity Detects TNFSF15(TL1A).
Gene TNFSF15(TL1A)
Other Names TL1; TL1A; VEGI; TNLG1B; VEGI192A
Gene ID 9966
Background The protein encoded by TNFSF15 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells but is not expressed in either B or T cells. The expression of this protein is inducible by TNF-alpha and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-κB and MAPK signalling pathways and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat. No：GM-58915AB
Product：Anti-H_TNFSF15(TL1A) hIgG1 Antibody(Tulisokibart、PRA-023)
GM-58915AB-10 10 μg
GM-58915AB-100 100 μg
GM-58915AB-1000 1 mg
Species Reactivity Human
Clone Tulisokibart/PRA-023
Source/Isotype Monoclonal Human IgG1 /κ
Application Flow Cytometry; Block assay
Specificity Detects TNFSF15(TL1A).
Gene TNFSF15(TL1A)
Other Names TL1; TL1A; VEGI; TNLG1B; VEGI192A
Gene ID 9966
Background The protein encoded by TNFSF15 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells but is not expressed in either B or T cells. The expression of this protein is inducible by TNF-alpha and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-κB and MAPK signalling pathways and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
