Cat.No：GM-30166AB
Product：Anti-H_CEACAM6(CD66c) hIgG1 Antibody(Tinurilimab)
Cat.No：GM-30166AB
Product：Anti-H_CEACAM6(CD66c) hIgG1 Antibody(Tinurilimab)
GM-30166AB-10 10 μg
GM-30166AB-100 100 μg
GM-30166AB-1000 1mg
Species Reactivity Human
Clone Tinurilimab
Source/Isotype Monoclonal human IgG1, κ
Application Flow Cytometry
Specificity Detects CEACAM6
Gene CEACAM6
Other Names NCA; CEAL
Gene ID 4680(human)
Background Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) is a cell adhesion receptor of the immunoglobulin-like superfamily (3 Ig-like domains), known to interact with other CEACAMs through cis and transforming dimers via their N-terminal IgG V-domain. CEACAM6 is anchored to the cell membrane via a glycophosphatidylinositol (GPI) anchor at its C terminus and regulates cell adhesion, proliferation, signaling in cancer, and immunity. CEACAM6 elaborates an extracellular matrix (ECM) interactome via homotypic and/or heterotypic binding, promoting fibronectin (FN1)-integrin (ITGA1 and ITGB1) interactions. Over-expression of CEACAM6 is documented in many human epithelial (e.g., colorectal, breast, pancreatic ductal adenocarcinoma (PDA)) and hematologic malignancies (e.g., multiple myeloma and acute lymphoblastic leukemia).
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-30166AB
Product：Anti-H_CEACAM6(CD66c) hIgG1 Antibody(Tinurilimab)
GM-30166AB-10 10 μg
GM-30166AB-100 100 μg
GM-30166AB-1000 1mg
Species Reactivity Human
Clone Tinurilimab
Source/Isotype Monoclonal human IgG1, κ
Application Flow Cytometry
Specificity Detects CEACAM6
Gene CEACAM6
Other Names NCA; CEAL
Gene ID 4680(human)
Background Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) is a cell adhesion receptor of the immunoglobulin-like superfamily (3 Ig-like domains), known to interact with other CEACAMs through cis and transforming dimers via their N-terminal IgG V-domain. CEACAM6 is anchored to the cell membrane via a glycophosphatidylinositol (GPI) anchor at its C terminus and regulates cell adhesion, proliferation, signaling in cancer, and immunity. CEACAM6 elaborates an extracellular matrix (ECM) interactome via homotypic and/or heterotypic binding, promoting fibronectin (FN1)-integrin (ITGA1 and ITGB1) interactions. Over-expression of CEACAM6 is documented in many human epithelial (e.g., colorectal, breast, pancreatic ductal adenocarcinoma (PDA)) and hematologic malignancies (e.g., multiple myeloma and acute lymphoblastic leukemia).
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
