Cat. No：GM-87349MAB
Product：Anti-H_ITGB6 hIgG1 Reference Antibody (h2A2)
Cat. No：GM-87349MAB
Product：Anti-H_ITGB6 hIgG1 Reference Antibody (h2A2)
GM-87349MAB-1mg / 1 mg
GM-87349MAB-5mg / 5 mg
GM-87349MAB-25mg / 25 mg
GM-87349MAB-50mg / 50mg
GM-87349MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target ITGB6
Clone h2A2
Alternative Names Integrin beta-6
Source/Isotype Human IgG1(KDEL), Kappa
Application /
Description ITGB6 is the β6 subunit of the integrin αvβ6, which is a crucial subunit controlling the expression of the entire heterodimer αvβ6. (ITGB6) is the limiting subunit for the formation of the αvβ6 integrin, as it can only bind with αv. Therefore, the expression of the αvβ6 integrin depends on the transcriptional activity of the β6 integrin gene, which is only expressed in epithelial cells. The integrin αvβ6 is exclusively expressed on epithelial cells and is expressed at low levels in most normal healthy tissues. However, it is frequently upregulated in diseases such as cancer and fibrosis, with an estimated one-third of all solid tumors showing upregulation, which is associated with disease progression and poor prognosis. Multiple studies have shown that the severity of many cancers, including lung, breast, colon, gastric, and ovarian cancer, is related to the expression of αvβ6. In summary, αvβ6 plays a regulatory role in epithelial remodeling during development, tissue repair, and tumor formation.
Formulation Phosphate-buffered solution, pH 7.4.
Cat. No：GM-87349MAB
Product：Anti-H_ITGB6 hIgG1 Reference Antibody (h2A2)
GM-87349MAB-1mg / 1 mg
GM-87349MAB-5mg / 5 mg
GM-87349MAB-25mg / 25 mg
GM-87349MAB-50mg / 50mg
GM-87349MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target ITGB6
Clone h2A2
Alternative Names Integrin beta-6
Source/Isotype Human IgG1(KDEL), Kappa
Application /
Description ITGB6 is the β6 subunit of the integrin αvβ6, which is a crucial subunit controlling the expression of the entire heterodimer αvβ6. (ITGB6) is the limiting subunit for the formation of the αvβ6 integrin, as it can only bind with αv. Therefore, the expression of the αvβ6 integrin depends on the transcriptional activity of the β6 integrin gene, which is only expressed in epithelial cells. The integrin αvβ6 is exclusively expressed on epithelial cells and is expressed at low levels in most normal healthy tissues. However, it is frequently upregulated in diseases such as cancer and fibrosis, with an estimated one-third of all solid tumors showing upregulation, which is associated with disease progression and poor prognosis. Multiple studies have shown that the severity of many cancers, including lung, breast, colon, gastric, and ovarian cancer, is related to the expression of αvβ6. In summary, αvβ6 plays a regulatory role in epithelial remodeling during development, tissue repair, and tumor formation.
Formulation Phosphate-buffered solution, pH 7.4.
