Cat.No：GM-77399AB
Product：Anti-GFRAL hIgG1 Antibody(NGM-120)
Cat.No：GM-77399AB
Product：Anti-GFRAL hIgG1 Antibody(NGM-120)
GM-77399AB-10 10 μg
GM-77399AB-100 100 μg
GM-77399AB-1000 1 mg
Species Reactivity Human
Clone NGM-120
Source/Isotype Monoclonal human IgG1, κ
Application Bioactivity-ELISA
Specificity Detects GFRAL
Gene GFRAL
Other Names C6orf144, GRAL, UNQ9356, bA360D14.1
Gene ID 389400 (human);
Background GFRAL (GDNF Family Receptor Alpha Like) encodes a receptor protein associated with the GDNF (Glial Cell Line-Derived Neurotrophic Factor) family. NGM120 is a monoclonal antibody developed by the biopharmaceutical company NGM Biopharmaceuticals, specifically targeting the GFRAL-GDF15 signaling pathway. It works by blocking the binding of GDF15 to its receptor GFRAL, thereby inhibiting the activation of this signaling pathway. The development of NGM120 is primarily aimed at addressing cancer cachexia and certain metabolic diseases, while also exploring its potential role in cancer treatment.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-77399AB
Product：Anti-GFRAL hIgG1 Antibody(NGM-120)
GM-77399AB-10 10 μg
GM-77399AB-100 100 μg
GM-77399AB-1000 1 mg
Species Reactivity Human
Clone NGM-120
Source/Isotype Monoclonal human IgG1, κ
Application Bioactivity-ELISA
Specificity Detects GFRAL
Gene GFRAL
Other Names C6orf144, GRAL, UNQ9356, bA360D14.1
Gene ID 389400 (human);
Background GFRAL (GDNF Family Receptor Alpha Like) encodes a receptor protein associated with the GDNF (Glial Cell Line-Derived Neurotrophic Factor) family. NGM120 is a monoclonal antibody developed by the biopharmaceutical company NGM Biopharmaceuticals, specifically targeting the GFRAL-GDF15 signaling pathway. It works by blocking the binding of GDF15 to its receptor GFRAL, thereby inhibiting the activation of this signaling pathway. The development of NGM120 is primarily aimed at addressing cancer cachexia and certain metabolic diseases, while also exploring its potential role in cancer treatment.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
