Cat. No：GM-87876MAB
Product：Anti-TNFRSF9(4-1BB) hIgG4 Reference Antibody (Urelbio)
Cat. No：GM-87876MAB
Product：Anti-TNFRSF9(4-1BB) hIgG4 Reference Antibody (Urelbio)
GM-87876MAB-1mg / 1 mg
GM-87876MAB-5mg / 5 mg
GM-87876MAB-25mg / 25 mg
GM-87876MAB-50mg / 50 mg
GM-87876MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target TNFRSF9
Clone Urelumab
Alternative Names 4-1BB, A930040I11Rik, CDw137, Cd137, ILA, Ly63
Source/Isotype Monoclonal Human IgG4(S228P), Kappa
Application Activation assay; Flow cytometry
Description 4-1BB (CD137) is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cells. Its ligand, 4-1BBL (CD137L), is mainly expressed on antigen-presenting cells (APCs) such as dendritic cells and macrophages. 4-1BB plays a critical role in the immune system, particularly in regulating T cell activation, proliferation, and survival. Urelumab binds to 4-1BB and activates the co-stimulatory signaling of T cells and NK cells, thereby enhancing anti-tumor immune responses. As a representative 4-1BB agonist, Urelumab has shown significant potential in boosting anti-tumor immune responses, despite being limited by toxicity issues in early studies.
Formulation phosphate-buffered solution, pH 7.4
Cat. No：GM-87876MAB
Product：Anti-TNFRSF9(4-1BB) hIgG4 Reference Antibody (Urelbio)
GM-87876MAB-1mg / 1 mg
GM-87876MAB-5mg / 5 mg
GM-87876MAB-25mg / 25 mg
GM-87876MAB-50mg / 50 mg
GM-87876MAB-100mg / 100 mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target TNFRSF9
Clone Urelumab
Alternative Names 4-1BB, A930040I11Rik, CDw137, Cd137, ILA, Ly63
Source/Isotype Monoclonal Human IgG4(S228P), Kappa
Application Activation assay; Flow cytometry
Description 4-1BB (CD137) is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cells. Its ligand, 4-1BBL (CD137L), is mainly expressed on antigen-presenting cells (APCs) such as dendritic cells and macrophages. 4-1BB plays a critical role in the immune system, particularly in regulating T cell activation, proliferation, and survival. Urelumab binds to 4-1BB and activates the co-stimulatory signaling of T cells and NK cells, thereby enhancing anti-tumor immune responses. As a representative 4-1BB agonist, Urelumab has shown significant potential in boosting anti-tumor immune responses, despite being limited by toxicity issues in early studies.
Formulation phosphate-buffered solution, pH 7.4
