Cat.No：GM-88299AB
Product ：Anti-CD8A hIgG4 Antibody(REGN5054)
Cat.No：GM-88299AB
Product ：Anti-CD8A hIgG4 Antibody(REGN5054)
GM-88299AB-10 10 μg
GM-88195AB-100 100 μg
GM-88195AB-1000 1mg
Species Reactivity | Human |
Clone | REGN5054 |
Source/Isotype | hIgG4 (S228P), Kappa |
Application | Flow Cytometry |
Target | Detects CD8A |
Gene | CD8A |
Other Names | CD8, CD8alpha, IMD116, Leu2, p32 |
Gene ID | 926 (Human) |
Background | D8β, together with CD8α, forms the CD8 receptor on the T cell surface. It mainly enhances TCR signaling by binding to peptide antigens presented by MHC I, thereby increasing CTL cytotoxicity against target cells. At the gene level, CD8A and CD8B encode CD8α and CD8β, and their expression is influenced by development, activation, and the microenvironment, with important implications for tumor immune surveillance, chronic infection, and immune exhaustion-related diseases. Anti-CD8 antibodies are widely used for flow cytometry to characterize CD8+ T cell subsets and exhaustion/activation phenotypes, for immunohistochemistry/immunofluorescence to assess tumor infiltration and spatial distribution, and for evaluating immunotherapies and studying function in animal models. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
Cat.No：GM-88299AB
Product ：Anti-CD8A hIgG4 Antibody(REGN5054)
GM-88299AB-10 10 μg
GM-88195AB-100 100 μg
GM-88195AB-1000 1mg
Species Reactivity | Human |
Clone | REGN5054 |
Source/Isotype | hIgG4 (S228P), Kappa |
Application | Flow Cytometry |
Target | Detects CD8A |
Gene | CD8A |
Other Names | CD8, CD8alpha, IMD116, Leu2, p32 |
Gene ID | 926 (Human) |
Background | D8β, together with CD8α, forms the CD8 receptor on the T cell surface. It mainly enhances TCR signaling by binding to peptide antigens presented by MHC I, thereby increasing CTL cytotoxicity against target cells. At the gene level, CD8A and CD8B encode CD8α and CD8β, and their expression is influenced by development, activation, and the microenvironment, with important implications for tumor immune surveillance, chronic infection, and immune exhaustion-related diseases. Anti-CD8 antibodies are widely used for flow cytometry to characterize CD8+ T cell subsets and exhaustion/activation phenotypes, for immunohistochemistry/immunofluorescence to assess tumor infiltration and spatial distribution, and for evaluating immunotherapies and studying function in animal models. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
