Cat.No：GM-88302AB
Product ：Anti-CD8B hIgG1 Antibody(xhCD8v12)
Cat.No：GM-88302AB
Product ：Anti-CD8B hIgG1 Antibody(xhCD8v12)
GM-88302AB-10 10 μg
GM-88302AB-100 100 μg
GM-88302AB-1000 1mg
Species Reactivity | Human |
Clone | xhCD8v12 |
Source/Isotype | Human IgG1,Kappa |
Application | Flow Cytometry |
Target | Detects CD8B |
Gene | CD8B |
Other Names | CD8B1, CD8beta, LEU2, LY3, LYT3, Ly-3, P37 |
Gene ID | 926 (Human) |
Background | CD8B gene encodes the CD8β chain, an important component of the CD8 co-receptor that, together with CD8α, forms a cell-surface dimer. It aids CD8+ T cells in recognizing antigenic peptides presented by MHC I, enhancing cytotoxic responses, and it participates in signaling, proliferation, and the formation of memory T cells. Research focuses on expression changes and functional regulation of CD8β in tumor immunity, autoimmunity, and immune regulation, exploring strategies to boost anti-tumor immunity or mitigate autoimmune responses by modulating the CD8β pathway. In terms of antibody applications, the core approaches include monoclonal antibodies and bispecific antibodies against CD8β for cell sorting and functional blockade or enhancement, potential applications of antibody-drug conjugates and immunotherapy combinations, and marking/detection for diagnostic and immunophenotyping analyses. In cell therapy, CD8β antibodies can also be used for sorting, labeling, or modulating humanized T cells. Experimental design should pay attention to antibody specificity, epitope targeting, cross-species reactivity, and the impact of sample fixation state on different applications, while integrating multi-omics data to comprehensively interpret the function and clinical potential of CD8β. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
Cat.No：GM-88302AB
Product ：Anti-CD8B hIgG1 Antibody(xhCD8v12)
GM-88302AB-10 10 μg
GM-88302AB-100 100 μg
GM-88302AB-1000 1mg
Species Reactivity | Human |
Clone | xhCD8v12 |
Source/Isotype | Human IgG1,Kappa |
Application | Flow Cytometry |
Target | Detects CD8B |
Gene | CD8B |
Other Names | CD8B1, CD8beta, LEU2, LY3, LYT3, Ly-3, P37 |
Gene ID | 926 (Human) |
Background | CD8B gene encodes the CD8β chain, an important component of the CD8 co-receptor that, together with CD8α, forms a cell-surface dimer. It aids CD8+ T cells in recognizing antigenic peptides presented by MHC I, enhancing cytotoxic responses, and it participates in signaling, proliferation, and the formation of memory T cells. Research focuses on expression changes and functional regulation of CD8β in tumor immunity, autoimmunity, and immune regulation, exploring strategies to boost anti-tumor immunity or mitigate autoimmune responses by modulating the CD8β pathway. In terms of antibody applications, the core approaches include monoclonal antibodies and bispecific antibodies against CD8β for cell sorting and functional blockade or enhancement, potential applications of antibody-drug conjugates and immunotherapy combinations, and marking/detection for diagnostic and immunophenotyping analyses. In cell therapy, CD8β antibodies can also be used for sorting, labeling, or modulating humanized T cells. Experimental design should pay attention to antibody specificity, epitope targeting, cross-species reactivity, and the impact of sample fixation state on different applications, while integrating multi-omics data to comprehensively interpret the function and clinical potential of CD8β. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
